Coumarins and derivatives
Medchemexpress LLC 7-Ethoxy-4-methylcoumarin | 87-05-8 | 99.44% | 1 G
7-Ethoxy-4-methylcoumarin is a coumarin derivative used as a substrate probe for mammalian cytochromes P450 1A1, 2B4, and 2B6.
- Coumarin derivative
- Used as a substrate probe
- Targets cytochromes P450 1A1, 2B4, and 2B6
Apexbio Technology LLC Esculin 531-75-9 20mg
Esculin (CAS 531-75-9) is a coumarin glucoside isolated from the bark of Aesculus hippocastanum It functions primarily as a -glucosidase substrate hydrolyzing to esculetin and glucose upon enzymatic action Esculin s fluorescence properties make it valuable in assays monitoring -glucosidase activity in microbiological and biochemical research Additionally its antioxidant and vasoprotective effects have supported investigations into microcirculatory disorders and oxidative stress-related models Esculin is soluble in hot ethanol methanol pyridine ethyl acetate and acetic acid and should be stored in sealed cool and dry conditions
Medchemexpress LLC AZP-531 | 1088543-62-7 | 99.8% | 962.02 | 1 MG
AZP-531 is an analogue of unacylated ghrelin for research use, designed to improve glycaemic control and reduce weight. It shows survival effects on pancreatic β-cells and human pancreatic islets, and is highly stable in human plasma in vitro with no degradation after one day at 37°C.
- Exhibits survival effects on pancreatic β-cells and human pancreatic islets.
- Stable in human plasma in vitro at 37°C for one day.
- Prevents high-fat diet-induced weight gain, proinflammatory effects, and prediabetic metabolic state in mice.
- Stimulates mitochondrial function markers in brown adipose tissue.
- Well-tolerated in clinical trials; improves glucose without increasing insulin.
- Reduces mean body weight and HbA1c in clinical trials.
Selleck Chemical LLC Esculetin S4711-1g
Esculetin (Cichorigenin Aesculetin) is a coumarin derivative found in various natural plant products with various biological and pharmaceutical properties including anti-edema anti-inflammatory and anti-tumour effects It inhibits lipoxygenases (LOs)
Medchemexpress LLC Linarin | 480-36-4 | 592.55 | 5 MG
Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). It exhibits various activities such as anti-inflammatory, antioxidant, sleep aid, sedation, bone differentiation, anti-tumor, antibacterial, and antiviral properties. Linarin can be utilized in research for diseases like nervous system disorders, osteoporosis, and cancer.
- Orally active and selective inhibitor of acetylcholinesterase (AChE)
- Possesses anti-inflammatory activity
- Exhibits antioxidant properties
- Acts as a sleep aid and sedative
- Promotes bone differentiation
- Shows anti-tumor effects
- Demonstrates antibacterial activity
- Has antiviral properties
- Can be used to study nervous system diseases, osteoporosis, and cancer
Selleck Chemical LLC Palomid 529 (P529) S2238-1g
Palomid 529 (P529 SG 00529) inhibits both the mTORC1 and mTORC2 complexes reduces phosphorylation of pAktS473 pGSK3 S9 and pS6 Phase 1
![Medchemexpress LLC 6H-dibenzo[b,d]pyran-6-one, 8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]- | 914913-88-5 | MFCD18633224 | 99.3% | C24H22O6 | 10MG](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000261568.png-250.jpg)
Medchemexpress LLC 6H-dibenzo[b,d]pyran-6-one, 8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methoxy]- | 914913-88-5 | MFCD18633224 | 99.3% | C24H22O6 | 10MG
Palomid 529 is a small-molecule research inhibitor that targets both mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), modulating the PI3K/Akt/mTOR signaling pathway. It has been used in preclinical studies and early clinical research to reduce tumor growth, angiogenesis, and vascular permeability, and has been investigated for neovascular age-related macular degeneration.
- Dual inhibition of mTORC1 and mTORC2.
- Documented in peer-reviewed literature and public chemical databases.
- High reported purity suitable for analytical use.
- Suitable as an analytical standard and research reagent.
- Provided with batch-specific certificate of analysis data.
Apexbio Technology LLC Palomid 529 914913-88-5 50mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
Medchemexpress LLC 4H-1-Benzopyran-4-one, 7-[[6-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(4-methoxyphenyl)- | 480-36-4 | 592.55 | 20 MG
Linarin (Buddleoside) is an orally active and selective inhibitor of acetylcholinesterase (AChE). It exhibits various activities including anti-inflammatory, antioxidant, sleep aid and sedation, bone differentiation, anti-tumor, antibacterial, and antiviral properties. Linarin can be utilized in the study of diseases affecting the nervous system, osteoporosis, and cancer.
- Orally active and selective inhibitor of acetylcholinesterase (AChE).
- Anti-inflammatory properties.
- Antioxidant properties.
- Sleep aid and sedation.
- Promotes bone differentiation.
- Anti-tumor activity.
- Antibacterial properties.
- Antiviral properties.
- Useful for studying diseases such as those of the nervous system, osteoporosis, and cancer.
Medchemexpress LLC 4-Methylesculetin | 529-84-0 | 1 ML
4-Methylesculetin is an orally active coumarin derivative known for its potent antioxidant and anti-inflammatory properties. It demonstrates inhibitory effects on myeloperoxidase activity and offers protection against bone resorption by decreasing elevated levels of bone-joint exoglycosidases, cathepsin-D, and tartrate resistant acid phosphatases. This compound also helps ameliorate upregulated non-enzymatic inflammatory markers such as TNF-α, IL-1β, IL-6, COX-2, and PGE2, making it a promising subject for inflammatory disease research.
- Orally active coumarin derivative
- Potent antioxidant and anti-inflammatory activities
- Inhibits myeloperoxidase activity
- Protects against bone resorption
- Ameliorates upregulated non-enzymatic inflammatory markers
- Promising for research on inflammatory diseases
Apexbio Technology LLC Palomid 529 914913-88-5 10mg
Palomid 529 (CAS 914913-88-5) is a small-molecule inhibitor of the PI3K/Akt/mTOR signaling pathway targeting both TORC1 and TORC2 complexes It exhibits potent anti-proliferative activity in the NCI-60 cell line panel with GI50 values below 35 M In endothelial cell assays Palomid 529 inhibits VEGF- and bFGF-induced proliferation with IC50 values of 20 nM and 30 nM respectively The PI3K/Akt/mTOR pathway is implicated in tumor cell survival proliferation angiogenesis and resistance to apoptosis Palomid 529 has also demonstrated the ability to suppress radiation-induced expression of Id-1 VEGF MMP-2 and MMP-9 expanding its utility in studies of cancer biology and radiotherapy sensitization
![eMolecules 1256486-26-6 | 3-(7-Aza-2-benzimidazolyl)benzamidoxime | Oakwood Chemical | MFCD28166151 | 253.265 | C13H11N5O | 97.000 | N\C(=N/O)c1cccc(c1)-c1nc2cccnc2[nH]1 | 1g | 537705745](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502142956.JPG-250.jpg)
eMolecules 1256486-26-6 | 3-(7-Aza-2-benzimidazolyl)benzamidoxime | Oakwood Chemical | MFCD28166151 | 253.265 | C13H11N5O | 97.000 | N\C(=N/O)c1cccc(c1)-c1nc2cccnc2[nH]1 | 1g | 537705745
3-(7-Aza-2-benzimidazolyl)benzamidoxime | Oakwood Chemical | 1256486-26-6 | MFCD28166151 | 253.265 | C13H11N5O | 97.000 | N\C(=N/O)c1cccc(c1)-c1nc2cccnc2[nH]1 | 1g | 537705745